Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 2

Year

2017 1

2013 1

Keywords

Artemisia annua 1

Artemisia annua L. 1

Cd 1

anti-solvent crystallization 1

artemisinin 1

gene expressions 1

quercetin 1

secondary metabolites 1

solubility 1

open ︾

Search scope:

排序： Display mode:

Effects of different doses of cadmium on secondary metabolites and gene expression in Artemisia annua

Liangyun Zhou,Guang Yang,Haifeng Sun,Jinfu Tang,Jian Yang,Yizhan Wang,Thomas Avery Garran,Lanping Guo

Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 137-146 doi: 10.1007/s11684-016-0486-3

Abstract: effects of different Cd concentrations (0, 20, 60, and 120 μmol/L) on the biosynthesis of Artemisiaannua L. were examined.

Keywords： Cd secondary metabolites gene expressions Artemisia annua L.

HTML PDF Collect

Purification of artemisinin from quercetin by anti-solvent crystallization

Chandrakant R. MALWADE, Haiyan QU, Ben-Guang RONG, Lars P. CHRISTENSEN

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 72-78 doi: 10.1007/s11705-013-1305-x

Abstract: In the present work, anti-solvent crystallization of artemisinin from four different organic solvents (methanol, ethanol, acetonitrile, and acetone) was studied. Water was used as anti-solvent. The effect of an impurity (quercetin) on the performance of anti-solvent crystallization of artemisinin was investigated. The fundamental process data such as solubility of artemisinin in pure organic solvents and their binary mixtures with varying composition water were measured at room temperature. The solubility of quercetin was measured only in pure organic solvents at room temperature. Anti-solvent crystallization experiments were designed based on the fundamental process data determined. Firstly, the anti-solvent crystallization of artemisinin without impurity was performed from all four organic solvents and then the experiments were repeated with addition of an impurity (quercetin) while keeping all other process parameters constant. Two different concentrations of impurity, i.e., 10% and 50% of its solubility, in the respective organic solvents at room temperature were used. The effect of impurity on performance of anti-solvent crystallization was evaluated by comparing the yield and purity of the artemisinin obtained with those in the absence of impurity. Results of the present work demonstrated that the presence of quercetin in the solution does not affect the final yield of artemisinin from the solution of each of four organic solvents used. However, the purity of artemisinin crystals were reduced when quercetin concentration was 50% of its solubility in all solvents studied.

Keywords： anti-solvent crystallization artemisinin quercetin solubility Artemisia annua